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Series comprises Ronald St. John Macdonald's records regarding his professional activities, including his involvement with different organizations, such as the Council of Europe, the European Court of Human Rights, the Hague, World Academy of Arts and Science, Canadian Council of International Law, United Nations, Institute of International Law, African Society of International Law, British Institute of International Law, Canadian Institute of International Law, International Law Association, and others. Series contains meeting agendas, meeting minutes, newsletters, reports, and other records.

Series comprises correspondence regarding Macdonald's professional and academic involvement with institutions including Osgoode Hall, University of Western Ontario, University of Toronto, Dalhousie University, the European Court of Human Rights, the Hague, Peking University, World Academy of Arts and Science, Canadian Council of International Law, United Nations, Institute of International Law, African Society of International Law, British Institute of International Law, Canadian Institute of International Law, International Law Association, and others. Series also contains correspondence between Ronald St. John Macdonald and individuals including Joseph Philippe Pierre Yves Elliott Trudeau, Paul E. Martin, Jean Chrétien, Elisabeth Mann Borgese, Wang Tieya, A. Donat Pharand, and others.

Series is comprised of materials related to the 1961 Cornell-Aro Research Project in the Western Region and the 1963 Study on the Role of Women. In the Cornell-Aro study, modeled on the Stirling County Study, Leighton’s team analyze the mental health trends of Nigerians living in both major cities and small rural villages via interviews, surveys, and observations. The Role of Women study may possibly be considered a ‘sub-study’ of the Cornell-Aro study, as it uses much of the same research material supplemented by new data. Materials present include correspondence, memoranda, datasets, research notes, fieldnotes reports, speeches, photographs, forms, applications, surveys and questionnaires, medical documents, affiliated studies, and comparative analyses.